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KMID : 0352720060300040194
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Journal of Ginseng Research
2006 Volume.30 No. 4 p.194 ~ p.198
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The Effect of Red Ginseng on Ultraviolet B-induced Skin Damages in Mouse
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Lee Hae-June
Kim Seong-Ho
Jo Sung-Kee
Moon Chang-Jong
Kim Jong-Choon
Bae Chun-Sik
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Abstract
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The effects of red ginseng (RG) on the changes of ultraviolet (UV) light B radiation-induced apoptotic sun-burn cell (SBC) and epidermal ATPase-positive dendritic cell (DC) in SKH 1-hr or ICR mouse were investigated. The mice were treated with UVB (200mJ/cm^2) and were sacrificed 24 hours later. RG (50 mg/kg of body weight) or vehicle (saline) was given i.p. at 36 and 12 hours before irradiation, and 30 minutes after irradiation. RG cream (0.2%) or cream base (vehicle) was also topically treated at 24 hours and 15 minutes before irradiation, and immediately after irradiation. The skin of SKH 1-hr mouse prepared from the back of untreated mice exhibited about 0.3 SBC/cm length of epidermis, and 24 hours after UV irradiation, the applied areas show an increased number of SBCs. But the frequency of UVB-induced SBC formation was significantly reduced by intraperitoneal injection of RG extract. The numbers of DC in normal ICR mouse were 628.00{pm}51.56;or;663.20{pm}62.58;per;mm^2 of ear epidermis. By 1 day after UVB treatment, the number of ATPase-positive cells/mm^2 were decreased by 39.0% or 27.1% in i.p. or topical application group with vehicle. The frequency of UVB (200mJ/cm^2)-induced DC decrease was reduced by treatment of RG as 31.3% in i.p. group and 22.4% in topical application group compared with the irradiation control group. The results presented herein that RG administration could reduce the extent of skill damages produced by UVB.
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KEYWORD
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ultraviolet B, sunburn cell, ATPase-positive dendritic cell, red ginseng
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